Bioorthogonal photocatalytic activation of anticancer metal complexes
Bioorthogonal catalysis is a chemical toolkit to perform highly selective and efficient reactions in biological environments (e.g. cells), avoiding off target reactions with biological components. The discovery of new bioorthogonal strategies may result in novel concepts for drug design and development.
In this project we employ flavins as photocatalysts and anticancer metal complexes as unconventional substrates to achieve the generation of cytotoxic metal-based species with extremely low light doses and bioorthogonal selectivity.
Spanish State Research Agency - grants PID2019-109111RB-I00 and RED2018-102471-T